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2 3-Butanedione-2-monoxime (BDM CAS 57-71-6) is a small molecule inhibitor of myosin ATPase activity By interfering with the ATP-driven cross-bridge cycling of myosin BDM disrupts the conversion of chemical energy into mechanical force impacting cytoskeletal dynamics In vitro studies have shown that treatment with BDM in fission yeast leads to reduced cell size increased septation and altered actin organization though cytokinetic actin ring formation is maintained BDM is widely employed as a reversible probe of myosin function in muscle and cell biology research to elucidate contractile mechanisms and cytoskeletal behaviors
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Milbemycin oxime is an orally active macrolide that exhibits broad-spectrum antiparasitic activity. It is comprised of oxime derivatives corresponding to milbemycin A4 and A3. This compound functions by binding to glutamate-gated chloride channels, thereby demonstrating inhibitory effects against various internal parasites, including intestinal nematodes and lung/heart worms.
Exhibits broad-spectrum action against parasites.
Active when administered orally.
Targets specific ion channels in parasites.
Effective against various types of worms.
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TRAIL Protein (TNFSF10) a member of the TNF superfamily is a type II transmembrane protein TRAIL Protein mainly interacts with TRAIL-R1 and TRAIL-R2 and induces apoptosis in tumor or infected cells TRAIL Protein also binds with DR4 DR5 and OPG TRAIL Protein can recruit FADD and further recruit and activates caspase-8 after binding to DR4 or DR5 Besides TRAIL may also trigger nonapoptotic signaling through activating pro-inflammatory pathways[1][2] TRAIL protein is mainly expressed on surface of immune cells such as cytotoxic T cells and natural killer (NK) cell[1] TRAIL/TNFSF10 Protein Human (HEK293 His-Flag) is a recombinant human TRAIL (G118-G281) with N-terminal His and Flag tag which is expressed in HEK293
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